李文

学习及工作经历

2005.09~2010.07     天津医科大学  预防医学专业  学士

2010.09~2015.07     天津医科大学  营养与食品卫生专业  博士（硕博连读）

2015.07~2018.12     天津医科大学 营养与食品卫生学系 讲师

2018.12~今     天津医科大学 营养与食品卫生学系 副教授

研究领域

营养与神经科学

代表性论文

Xinyan Wang#, Zhenshu Li, Yun Zhu, Jing Yan, Huan Liu, Guowei Huang, Wen Li*. Maternal Folic Acid Impacts DNA Methylation Profile in Male Rat Offspring implicated in Neurodevelopment and Learning/Memory Abilities. Genes & Nutrition. 2021 Jan 11;16(1):1. doi: 10.1186/s12263-020-00681-1.（IF=4.258）

Ling Huang#, Jing Zhao, Yongjie Chen, Fei Ma, Guowei Huang, Wen Li*. Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review. Aging & Mental Health. 2021 Jan 19:1-8. doi: 10.1080/13607863.2021.1875194. （IF=2.478）

Mengyue Li#, Wen Li#, Yiming Gao, Yongjie Chen, Dong Bai, Jinxi Weng, Yue Du, Fei Ma, Xinyan Wang, Huan Liu, Guowei Huang*. Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial. European Journal of Nutrition. 2021 Jun;60(4):1795-1808. doi: 10.1007/s00394-020-02373-3.（IF=4.664）

Wen Li#, Yue Ma#, Zhenshu Li, Xin Lv, Xinyan Wang, Dezheng Zhou, Suhui Luo, John X. Wilson, Guowei Huang*. Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition. International Journal of Molecular Sciences. 2019 Dec 20,21(1). pii: E62. doi: 10.3390/ijms21010062. (IF=4.556）

Xin Lv#, Dongtao Zhou, Baojin Ge, Hui Chen, Yue Du, Shuai Liu, Yong Ji, Changqing Sun，Guangshun Wang, Yuxia Gao, Wen Li*, Guowei Huang*. Association of folate metabolites and mitochondrial function in peripheral blood cells in Alzheimer’s disease: a matched case-control study. Journal Alzheimer Disease. 2019,70(4):1133-1142. doi: 10.3233/JAD-190477. (IF=3.909）

Wen Li#, Zhenshu Li, Shou Li, Xinyan Wang, John X. Wilson, Guowei Huang*. Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring. Nutrients. 2018 Mar 1,10(3). pii: E292. doi: 10.3390/nu10030292. (IF=4.546）

Wen Li#, Huan Liu, Min Yu, Xumei Zhang, Yan Zhang, Hongbo Liu, John X. Wilson, Guowei Huang*. Folic acid alters methylation profile of JAK-STAT and long-term depression signaling pathways in Alzheimer’s disease models. Molecular Neurobiology. 2016 Nov,53(9):6548-6556. doi: 10.1007/s12035-015-9556-9. (IF=4.500）

Huan Liu#, Wen Li#, Shijing Zhao, Xumei Zhang, Meilin Zhang, Yanyu Xiao, John X. Wilson, Guowei Huang*. Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells. European Journal of Nutrition. 2016 Aug,55(5):1849-62.  doi: 10.1007/s00394-015-1002-2.（IF=4.664）

Wen Li#, Mingyue Jiang, Shijing Zhao, Huan Liu, Xumei Zhang, John X. Wilson, Guowei Huang*. Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells. International Journal of Molecular Sciences. 2015 Oct 20,16(10):25002-13. doi:10.3390/ijms161025002. (IF=4.556）

 Wen Li#, Huan Liu, Min Yu, Xumei Zhang, Meilin Zhang, John X. Wilson, Guowei Huang*. Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. Journal of Nutritional Biochemistry. 2015 Aug,26(8):883-91. doi: 10.1016/j.jnutbio.2015.03.009. (IF=4.873）